Showing posts with label IVIG. Show all posts
Showing posts with label IVIG. Show all posts

Sunday, 18 December 2016

38w4d in denial about being pregnant

I found out I was pregnant at 3w2d and went to the doctor straight away. My betas were 11 and they did my first round of IVIG but were hesitant to offer any congratulations, saying that I needed at least a 50 on the betas. I knew that 11 was low, but I also knew that I found out I was pregnant pretty early. Three days later my betas were 80 and I was officially declared pregnant and told my due date was 28 December 2016. For the first 12 weeks I was scared of miscarrying even though I was on IVIG, baby aspirin, and progesterone cream. They say 1 in 3 women miscarry and with high NK cells I'm sure my odds of miscarrying were higher.

After 12 weeks I was feeling better and just hoped to make it to 24 weeks, which is considered viability. Then at 20w7d I started leaking fluid. After a few stressful hours in the early morning in the ER I found out that everything was ok.

I made it passed my second trimester and was smack dab in the middle of my third when I found out at 34w7d that the baby, who had always been at or ahead of dates, was now a few weeks behind. I know that at that point measurements can vary by as many as 4 weeks. However, it's not very comforting when everything was measuring fine before then. Two weeks later, the measurements were better, but still didn't match up so they pushed the due date back until 6 January 2017. The doctor seemed not to worry and induction was never mentioned. I know in the US they seem to induce by 39 weeks at the latest when there are immune issues involved. I guess Korea is different. I'm honestly surprised I got this far. My water broke with my daughter early in the morning at 37w2d and she was born at 37w4d. Now I'm 38w4d and I have a feeling I will be late.

I think due to the miscarriages I had before I don't want to get my hopes up. I know I'm pregnant, but I'm in denial. It's hard for me to connect to the baby. It feels weird to think that there's a little human inside of me. I definitely don't feel as excited as I did when I was pregnant with my daughter. I just want to get this all over with and have a healthy baby. I only got sick once in the first trimester and started wearing maternity clothes in my first trimester. I had some bad leg cramps in the second trimester. I've also been having Braxton Hicks throughout the third trimester. I haven't gained much weight. In fact, I haven't gained any weight since 21 weeks, but my belly keeps getting bigger.

I've finally started taking some photos of me being pregnant, but nothing like when I was pregnant with my daughter and took weekly photos. I feel more cold and objective. I file all the paperwork and organise the ultrasounds so that I can make a claim with my insurance. I have all the paperwork we need to get the baby's American passport, CRBA, and SSN as well the the Peruvian passport, DNI, and birth certificate. But the excitement's not there. I'm just holding my breath hoping that everything will be ok. My doctor is supportive. Surprisingly they haven't said anything about me having a home birth.

I also feel like a part of my freedom is being taken away. My daughter just turned 5 a few months ago. She was breastfed until she was 4 and we co-slept until she was nearly 4.5 years old. She still sneaks into my bed in the morning. But now she's independent. She can get dressed, get herself food, I can leave her alone in the bath, she picks up her toys. I can have some me time. Once the baby comes, all that will go away. I'll be starting over for the next 5 years. This baby was very much planned and wanted, but I still have mixed feelings about the whole thing. Soon, this pregnancy will come to an end and we will have another little human in the house.

For more info, you can see how much this has cost, I also have a summary of dates, as well as my Rx protocol

Monday, 22 August 2016

21w5d and Intralipids #1

Today I should be getting another round of IVIG which would have been #7, however, they have decided to give me intralipids instead since everything is going well. I've heard from people that intralipids is fast, easy, and painless. It was not for me. I had no issues with IVIG, but intralipids hurt, made my arm feel heavy, and just made me feel weird. It took about 2.5 hours for them to do 400 ml of a 10% solution which is 10 gr.

Everything is normal. The baby is growing fine. They said it was a girl for the third time and I think my husband finally believes them.

Stats
  • BPD is 5.21 cm (21w7d).
  • FL is 4.03 cm (23w1d).
Money
  • Today I paid 133,780.
  • Doctor's visit: 32,270. 
  • Intralipids: 41,510. 
  • Ultrasound 60,000. 
  • Tricare (my insurance) reimbursed me for 32,273. 
  • Out of pocket was 101,507.
More info
For more info, you can see how much this has cost, I also have a summary of dates, as well as my Rx protocol

Friday, 29 July 2016

18w2d IVIG #6

Today I was told that I would not have anymore IVIG treatments. I was supposed to go to 23 weeks and I'm only at 18 weeks. The doctor said that since I started at 3 weeks instead of at 5 weeks and that the baby is measuring ok, I should be fine. I am very wary about stopping 5 weeks early and with only 6 treatments instead of 7, but they said I could do intralipids (which is egg, soybean, and other things) next time.

Stats
  • BPD is 4.31 cm (19w1d).
  • AC is 13.33 cm (18w7d).
  • FL is 3.13 cm (19w6d).
This appointment
Again, I was told that it was a girl but my husband is still in denial. Intralipids is often done instead of IVIG because it's cheaper. It also has similar results as IVIG, but only in the case where there is no known reason for miscarriages. Since we know that I have high NK cells, IVIG is supposed to be better. This is IVIG #6 and my last treatment. The IVIG is a 5% solution of 300 ml, which is 15 gr of IVIG.

I'm taking fish oil and Wobenyzme N, both of which are supposed to suppress NK cells and some people have said it's a natural alternative to IVIG or intralipids.

Money
  • Today I paid 381,410.
  • Doctor's visit: 32,260. 
  • IVIG #5: 289,150. 
  • Ultrasound 60,000. 
  • Tricare (my insurance) reimbursed me for 33,942. 
  • Out of pocket was 347,468.
More info
For more info, you can see how much this has cost, I also have a summary of dates, as well as my Rx protocol

Friday, 8 July 2016

15w2d and IVIG #5

I did another round of IVIG. This is number 5. The IVIG is a 5% solution of 300 ml, which is 15 gr of IVIG. They also did a Fragile X syndrome screening and Quad test and said I would get the results in a week or so. (Edit: Everything is normal.) The baby is growing just fine and is measuring a few days ahead. We were told it was a girl, but my husband says it's too early to tell.

Stats
  • BPD is 3.17 cm (15w7d).
  • FL is 2.13 cm (16w4d).
Money
  • Today I paid 837,140.
  • Doctor's visit: 32,270. 
  • IVIG #5: 289,140. 
  • Ultrasound 60,000. 
  • Fragile X syndrome screening and Quad test 455,710. 
  • Tricare (my insurance) reimbursed me for 496,722. 
  • Out of pocket was 340,418.
More info
For more info, you can see how much this has cost, I also have a summary of dates, as well as my Rx protocol

Friday, 17 June 2016

12w2d 4D ultrasound and IVIG #4

My husband is back from his business trip and made it to the hospital with me. They did the 4D ultrasound this time. The baby kept moving around so we didn't get any good photos, but everything is ok and the baby is growing fine. I did another round of IVIG. This is number 4. The IVIG is a 5% solution of 300 ml, which is 15 gr of IVIG. They also did the 1st blood test to check for pregnancy hormones and Down's. If I don't hear anything then there's nothing wrong. (Update: I got a text about a week later saying the tests are normal.) I go back in 3 weeks. Maybe then I will start telling people.

Stats
  • CRL is 6.04 cm (12w5d).
  • BPD is 1.77 cm (12w6d).
  • FHR is 173 bpm.
Money
  • Today I paid 557,570.
  • Doctor's visit: 32,260. 
  • IVIG #4: 289,140. 
  • 1st sequential blood test: 146,160. 
  • 4D Ultrasound 90,000. 
  • Tricare (my insurance) reimbursed me for 142,732. 
  • Out of pocket was 414,768.
More info
For more info, you can see how much this has cost, I also have a summary of dates, as well as my Rx protocol

Thursday, 26 May 2016

9w1d and IVIG #3

The baby is growing and the heartbeat is fine.

Stats
  • I'm 8w6d.
  • The baby is measuring 9w1d. 
  • CRL is 2.32 cm (9w1d).
  • FHR is 180 bpm. 
Another round of IVIG (6 volumes). The IVIG is a 5% solution of 300 ml, which is 15 gr of IVIG. Next ultrasound will be a 4D one.

Money
  • Today I paid 381,400.
  • Doctor's visit: 32,260. 
  • IVIG #3: 289,140. 
  • Ultrasound 60,000. 
  • Tricare (my insurance) reimbursed me for 25,808. 
  • Out of pocket was 355,592.
More info
For more info, you can see how much this has cost, I also have a summary of dates, as well as my Rx protocol

Friday, 6 May 2016

6w2d heartbeat and IVIG #2

They heard and saw a strong heartbeat at 121 bpm which is right smack-dab where it should be. CRL is .41 cm (6w2d). Went for another round of IVIG, only 6 volumes this time which is down from 10 at 3w2d. The IVIG is a 5% solution of 300 ml, which is 15 gr of IVIG.

They also wanted to do more testing to make sure I didn't have any STDs or childhood diseases like MMR. I told them I had been vaccinated. They said unless it was in the last six months I had to get tested. I did opt out of the cervical cancer screening since I just had that done. I won't be doing more tests that I don't want to. I know they'll come back negative and it's just a waste of time and money.

I found this PDF about Normal Ranges ranges of Embryonic Length, Embryonic Heart Rate, Gestational Sac Diameter and Yolk Sac Diameter at 6–10 Weeks as well as this growth chart.

Money
  • Today I paid 669,280.
  • Doctor's visit: 37,700. 
  • IVIG #2: 289,142. 
  • Blood test 273,338. 
  • Urine test 6,100. 
  • Ultrasound 60,000.  
  • Tricare (my insurance) reimbursed me for 256,104. 
  • Out of pocket was 413,176.
More info
For more info, you can see how much this has cost, I also have a summary of dates, as well as my Rx protocol

Friday, 15 April 2016

3w2d Positive HPT on Wondfo. 1st betas 11 and IVIG #1

I had positive OPKs on Wondfo on the 4th and the 5th, which were CD12 and CD13. I had been testing every day since Wednesday April 13th since I knew that I got pregnant easily and I needed the IVIG as soon as I got a positive. And I was hoping I'd get it before the weekend since I was working Saturday at Sunday.

I usually get up and pee a few times at night. I took a test around 8am and I had already peed three times that morning. It was negative so I threw it away. Right before I left at 9am I went peed again and took the test out of the trash in hopes that I could hold it to the light and see a line. There it was! Very, very little. But there was a line!

I dropped my daughter off at school and then called the hospital and told them I'd be coming in right away. I brought the test with me and they did a blood test in order to confirm that I was pregnant. I was on CD23 and probably about 10dpo if you keep in mind that you usually ovulate 24-72 hours after a positive OPK. The doctor told me that my betas were only 11 and that was low. For reference less than 5 is pregnant. He told me that I had to get to 50 by Monday. (Some doctors count anything over 25 as pregnant. In theory anything over 5 is pregnant, but it's a possible pregnancy since there could be problems with implantation and you could end up with a chemical pregnancy). To be honest, I was kind of annoyed to hear that I was low. I was on CD23 and most people (who aren't obsessed with TTC) don't even test that early. For those who do, about 33% get a false negatives.

I was told that my thyroid function was normal. 

I asked to do the IVIG. My LMP was March 24th, so I was about 3 weeks and 2 days pregnant. Usually, they do the first IVIG at 5 weeks, but I knew that would be too late for me. They told me how much it would be and I flat out told them I couldn't afford it. The nurse told me that the doctor would charge me what he charged Koreans. I would start at 10 volumes which is 25 gr of IVIG and that is the high dosage for my weight. After the first treatment I would then would get a lower dosage of 6 volumes which is 15 gr until week 23.

The IVIG is an intravenous immunoglobulin transfusion, which is a blood product, but it's clear. It took about 2.5 hours to finish. The IVIG is a 5% solution of 500 ml, which is 25 gr of IVIG. I left home at 9am and got back at 5:30pm. Waiting for the bus and getting to the hospital takes about an hour each way.

When I got home I took another HPT. This time it was the early pregnancy Wondfo and it was negative. I couldn't believe I had done everything only to have miscarried again. A friend told me to wait until morning and take another test. I went to the store and bought FRER and at 4am I took the test and it barely came up positive. I looked at the early pregnancy Wondfo again and there was a very faint line. I guess I had to wait until it dried completely just like the first one that I took and saw the positive an hour later.

I know my betas will be at least 50 and although it's very tempting to take more HPTs and see if the line gets darker, I'm going to hold off until I know numbers. This is my 4th pregnancy in 6 months.

Money
  • Today I paid 543,760.
  • Doctor's visit: 12,410. 
  • IVIG #1: 469,190. 
  • Blood tests for thyroid and HCG: 62,160. 
  • Tricare (my insurance) reimbursed me for 119,316. 
  • Out of pocket was 424,444.
More info
For more info, you can see how much this has cost, I also have a summary of dates, as well as my Rx protocol

Monday, 28 March 2016

About

Updated 25 September 2017
I started this blog in late March 2016. I've recorded the costs for Pyeongtaek St. Mary's on this page. It includes testing and pre-natal care, but not the birth. I wanted to have a home birth with Danica the midwife and Jinny the doula from Mamas Birth Center. However, I ended up with an emergency C-section at Pyeongtaek St. Mary's.

Research and Online Support
I've put together a list of useful websites and articles that discuss immunological issues related to miscarriages. I found the Yahoo group immunology support to be very helpful. They also have a secret Facebook group called reproductive immunology support. In order to join the Facebook group, you'll either need to ask in the Yahoo group to be added or have someone already in the group add you.

Infertility Treatment in Korea
You can read more about these hospitals and clinics at Infertility Treatment Centers in Korea and Birthing Centers in Korea

My Medical History
First Pregnancy
I got pregnant the first month I tried in 2011. My daughter was born in October of 2011 at
Kim Ok Jin (Rosa) Agitanseun Natural Birth Center (김옥진조산원) in Ansan. I got divorced shortly after she turned 2 and I re-married in the summer of 2015. My husband has no children from his previous marriage.

First Miscarriage: Chemical Pregnancy
I had a suspected chemical pregnancy in November 2015. I didn't take a test, but I was late and ended up bleeding for about 10 days. Looking back on it now that I have more experience with miscarriages, I'm pretty sure I was pregnant then.

I went to Dr. Yoo Women's Hospital (유광사여성병원) in Seoul in early November 2015 to make sure I was ovulating. They did an ultrasound and checked my lining as well as did some blood tests and everything seemed fine. I never went back because  I found out I was pregnant a few days later in late November 2015.

Second Miscarriage: 6 Weeks
I went to the doctor at Soonchunhyang Hospital (SCH) in Seoul at 6 weeks in early December. The baby was measuring about 6 days behind what it was supposed to, but they assured me everything was fine even though my cycle was not based on 28 days.

I had a sinking feeling about it and went to IMom Obgyn in Pyeongtaek 2 weeks later in December 2015 to get a cheap ultrasound (you get what you pay for). There was dried blood on the sofa in the waiting room. The doctor there had a horrible bedside manner and just said, "miscarriage" and literally shooed me away, telling me to go back to Seoul.

Back in Seoul at Soonchunhyang Hospital (SCH), I was livid. I found out they had entered the wrong information about my medical history and then said then said that they had thought something was wrong at the previous appointment but neglected to tell me. When I said I wanted to file a formal complaint, they told me to email. Since it had been about 3 weeks since the baby had died and my husband and I weren't living together, I decided to get a D and C in January 2016 so I didn't risk hemorrhaging at home. I did it at SCH and to add insult to injury the paper I signed said I was getting an abortion (big difference), even though three ultrasounds had confirmed the baby had died.

I would never recommend Soonchunhyang Hospital (SCH) or IMom Obgyn due to the inexcusable mistakes and horrible bedside manner of the doctors. 

Third Miscarriage: Chemical Pregnancy
In March 2016 I got pregnant again, only to have a chemical pregnancy three days later and end up in the ER on Osan AB due to hemorrhaging. During this time they decided to draw 4 vials of blood. At this point I figured something was wrong, despite the doctor telling me it wasn't my fault and that it was bad luck. Three losses in five months just isn't normal.

What Could Have Caused the Miscarriages
All of these issues can cause implantation failure. Since my miscarriages occurred before or around 6 weeks, I thought that if I could stop my body from attacking the baby during implantation, then I should be able to carry a baby to term.You can see a list of everything I took/was given, such as IVs, hormones, vitamins, supplements, and medicine on my my Rx protocol.


Anatomical: Uterine abnormalities
Anything that is not normal is a uterine abnormality. Things such as the shape of your uterus, uterine scarring, and incompetent cervix (horrible name, it means weak cervix), can be it hard for the baby to implant and/or thrive.

Genetic: Chromosomal defects
Neither my husband nor I had been tested for anything so we didn't know if we could have been carriers, however, chromosomal defects in the baby could have caused miscarriages

Genetic: Thrombophilia
I thought I might have a type of thrombophilia disorder, such as antiphospholipid syndrome (APS), Factor V Leiden, or methylene tetra hydro folate reductas (MTHFR) because they can cause sticky blood and blood clots. This means that nutrients to the baby are cut off. That could explain why I had such early miscarriages.

Some people believe as many as 50% of the population has a type of MTHFR gene mutation (there are different kinds, such as homozygous and heterozygous). People with MTHFR cannot metabolize folic acid (the synthetic form of folate), so they should take folate. MTHFR living has more info on how to prepare for pregnancy if you have a MTHFR mutation. In order to thin my blood I started taking low dose aspirin at night before I went to bed. Taking pills at night cut down on my nausea. The doctor told me to stop using it at 10 weeks, but I continued throughout my entire pregnancy. I figured that if it wasn't broken, why change?

Hormones: LPD (Luteal Phase Defect)
Since my cycle was down to 23 days, I thought I might have a LPD. This means that the uterine living sheds too soon and the baby does not have enough time to implant into the lining. I took progesterone cream in order to help with this. It can also help so you don't get blood clots. If you use progesterone cream make sure it comes from natural sources. Emerita is recommended by Wray at Progesterone Therapy. On Amazon, Smoky Mountain Naturals is a best seller.

Here's some info on how to use progesterone cream by Wray Whyte. She has a bunch of information about progesterone therapy. I didn't use as high of a dosage as she suggested though. I only used 1/8 of a teaspoon twice a day. What works for me might not work for you.

B vitamins are also said to help with low progesterone. I was taking those as well.

Hormones: PCOS
I really didn't think I had PCOS (Polycystic Ovary Syndrome) because I had no symptoms; however, I know that not every woman has symptoms. PCOS causes you to have too much testosterone as well as irregular cycles and difficulty in having the endometrium lining to develop properly. 

Infectious Disease: Mycoplasma hominis 
Another plasma issue is mycoplasma hominis like ureaplasma urealyticum can be responsible for RPL (recurrent pregnancy loss). I tested negative for this but your body is constantly changing.

Infectious Disease: Ureaplasma Urealyticum
I also know I have a high level of ureaplasma urealyticum and that might be responsible for RPL (recurrent pregnancy loss). However, when I went to the doctors, I wasn't tested for it.If I still had a high level it didn't affect this last pregnancy, but maybe that's because the IVIG did something and lowered it.

Immunological: High NK Cells
I also found out that high NK cells might cause RPL and attack the baby. Some doctors believe high NK cells are caused by inflammation, such as endometriosis or an immune-related disease, such as lupus. I was not tested for either.

Traditionally, prednisolone/prednisone (steroids), IVIG, and intralipids have been used to treat high NK cells. These are available by prescription only. There are natural OTC alternatives to prednisolone, such as Licorice root (buy it from Amazon), Maca (buy it from Amazon), and Wobenzym N (buy it on Amazon). Wobenzym N actually has been proven to help with immune related pregnancy loss.

Sixth Doctor: What I Was Tested For
I then went to Pyeongtaek St. Mary's Hospital in Pyeongtaek since they were close and they had fertility treatments on their website. I later found out that they have a very high success rate for IVF (53.6%), have fluent English speakers in the international clinic, and are famous for fertility treatments. I am not a candidate for IUI or IVF. I can easily get pregnant on my own. I just have trouble staying pregnant. I'm seeing Dr. Jeongrae Lee, who is supposed to be a famous infertility doctor in Korea. He works a lot and is very nice. Never heard him speak a word of English, but they provide free translators, so I don't care. (ETA: I finally heard him speak English after my emergency C-section.)

They tested me for high NK cells, thyroid issues, and did an HSG test (I asked for a shot of ketorolac in the butt, it made the HSG painless for me, but I know other people have gotten the shot and it hasn't done anything. It cost me 5,000 won so I thought I would try). Only my NK cells were high; the other two tests came back negative. I was told that IVIG would help.

My Rx Protocol
I used progesterone cream (to help with a suspected LPD) and low dose aspirin (to help thin my blood). For my high NK cells, I was given prednisolone, IVIG, and intralipids. The doctor also suggested I take two OTC medicines. The first one was progesterone cream to help with a suspected LPD. If you use progesterone cream make sure it comes from natural sources. Emerita is recommended by Wray at Progesterone Therapy. On Amazon, Smoky Mountain Naturals is a best seller. The second was low dose aspirin to help thin my blood.

The doctor also suggested I take two OTC medicines. The first one was progesterone cream to help with a suspected LPD. If you use progesterone cream make sure it comes from natural sources. Emerita is recommended by Wray at Progesterone Therapy. On Amazon, Smoky Mountain Naturals is a best seller. The second was low dose aspirin to help thin my blood.

I had been taking both of those since I found information online from women who said it had helped them (which beings me back to the message I posted above about being proactive). I also took supplements. To find out more about the dosage of my prescription and over-the-counter medicines and when they were taken, please see my Rx protocol.



Summary of Dates
November 2015
  • Early Nov: Suspected CP (pregnancy #2: miscarriage #1)
  • Mid Nov: Confirmed ovulation
  • Late Nov: Positive HPT (pregnancy #3: miscarriage #2)

December 2015

January 2016

March 2016

April 2016

May 2016

June 2016

July 2016

August 2016

September 2016

October 2016 

November 2016 

December 2016
Read Stay Inside Baby's Privacy Policy and FTC Disclosure.